MovDisordV3, Main, Exploration, bibRecord, 001F74

Abnormal Cardiac [123I]-Meta-Iodobenzylguanidine Uptake in Multiple System Atrophy

Identifieur interne : 001F74 ( Main/Exploration ); précédent : 001F73; suivant : 001F75

Abnormal Cardiac [123I]-Meta-Iodobenzylguanidine Uptake in Multiple System Atrophy

Auteurs : Hiroshi Nagayama [Japon] ; Masayuki Ueda [Japon] ; Mineo Yamazaki [Japon] ; Yasuhiro Nishiyama [Japon] ; Makoto Hamamoto [Japon] ; Yasuo Katayama [Japon]

Source :

Movement disorders [ 0885-3185 ] ; 2010.

RBID : Pascal:10-0413315

Descripteurs français

Pascal (Inist)
- Atrophie multisystématisée, Pathologie du système nerveux, Captation.

English descriptors

KwdEn :
- Multiple system atrophy, Nervous system diseases, Uptake.

Abstract

[¹²³I]-Meta-iodobenzylguanidine (MIBG) myocardial scintigraphy is useful for distinguishing multiple system atrophy (MSA) from Parkinson disease. In this study, longitudinal observation using MIBG myocardial scintigraphy was carried out in patients with MSA to evaluate the association of myocardial MIBG uptake with clinical features. A total of 96 MIBG examinations were performed in 52 patients with MSA. The heart/mediastinum (H/M) ratio of MIBG uptake at 240 minutes after injection was below the lower limit in 16 patients with MSA (31.3%). Overall, the H/M ratio correlated with neither disease duration nor severity. In the follow-up observations, the H/M ratio did not show any specific trends, in contrast with the continuous decrease observed in patients with Parkinson's disease. This data clearly showed that cardiac MIBG uptake cannot necessarily be preserved in patients with MSA and that approximately 30% of patients with MSA showed decreased MIBG uptake without any correlation to disease duration or severity.

Affiliations:

Japon
Tokyo

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Le document en format XML

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<front><div type="abstract" xml:lang="en">[<sup>123</sup>
I]-Meta-iodobenzylguanidine (MIBG) myocardial scintigraphy is useful for distinguishing multiple system atrophy (MSA) from Parkinson disease. In this study, longitudinal observation using MIBG myocardial scintigraphy was carried out in patients with MSA to evaluate the association of myocardial MIBG uptake with clinical features. A total of 96 MIBG examinations were performed in 52 patients with MSA. The heart/mediastinum (H/M) ratio of MIBG uptake at 240 minutes after injection was below the lower limit in 16 patients with MSA (31.3%). Overall, the H/M ratio correlated with neither disease duration nor severity. In the follow-up observations, the H/M ratio did not show any specific trends, in contrast with the continuous decrease observed in patients with Parkinson's disease. This data clearly showed that cardiac MIBG uptake cannot necessarily be preserved in patients with MSA and that approximately 30% of patients with MSA showed decreased MIBG uptake without any correlation to disease duration or severity.</div>
</front>
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<name sortKey="Hamamoto, Makoto" sort="Hamamoto, Makoto" uniqKey="Hamamoto M" first="Makoto" last="Hamamoto">Makoto Hamamoto</name>
<name sortKey="Katayama, Yasuo" sort="Katayama, Yasuo" uniqKey="Katayama Y" first="Yasuo" last="Katayama">Yasuo Katayama</name>
<name sortKey="Nishiyama, Yasuhiro" sort="Nishiyama, Yasuhiro" uniqKey="Nishiyama Y" first="Yasuhiro" last="Nishiyama">Yasuhiro Nishiyama</name>
<name sortKey="Ueda, Masayuki" sort="Ueda, Masayuki" uniqKey="Ueda M" first="Masayuki" last="Ueda">Masayuki Ueda</name>
<name sortKey="Yamazaki, Mineo" sort="Yamazaki, Mineo" uniqKey="Yamazaki M" first="Mineo" last="Yamazaki">Mineo Yamazaki</name>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Abnormal Cardiac [123I]-Meta-Iodobenzylguanidine Uptake in Multiple System Atrophy

Abnormal Cardiac [123I]-Meta-Iodobenzylguanidine Uptake in Multiple System Atrophy

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri